In total, our literature review identified 206 cases of BRCA1/BRCA2 MINAS and, after excluding those cases reported by Rebbeck et al. (90), the mean(+SD) age at breast cancer diagnosis was 42.4 (+-10 years, n = 69 compared to 40.4 years in the Rebbeck et al. BRCA1/BRCA2 MINAS cohort and 41.9 (n = 9316) and 45.0 (n = 3370) in their BRCA1-only and BRCA2-only pathogenic variant carriers. This evidence concerns the gene BRCA2 and breast carcinoma.