AICDA and infection: However, a recent study indicated that the anti-SARS-CoV-2 memory B cell response evolves during the first 6 months after infection with an accumulation of Ig somatic mutations and the production of antibodies with increased neutralizing breadth and potency because of the persistence of antigens.72 The concentration upregulation of nuclear AID may promote IgH SHM and increase the neutralizing breadth of SARS-CoV-2 mutated strains.