Its disorders may mediate gene translocation between IgH and oncogene C-Myc, leading to the generation of B cell lymphomas.9,10 At the level of transcriptional regulation, TNF receptor families such as CD40, BAFF-R, TACI, and BCMA can activate the downstream NF-κB signals, including classical p65 and non-classical p52 NF-kb signals, to activate the transcription of Aicda. 11–15 The stimulation of BCR signaling alone did not increase the expression of AID, even though BCR plays an important role in B cell development and antibody affinity. Here, BCR is linked to B-cell non-Hodgkin lymphoma.