Several studies have shown the existence of heterogeneous cellular states of T cells in the tumor microenvironment (TME) and a large number of T cells with nontumor specificity, which largely reduces the effect of immunotherapy.2,3 Therefore, as immunotherapy evolves as a feasible strategy for better clinical outcomes, a large effort has been made to discover the features and dynamics of intratumoral and circulating CD8+ T cells responding to tumor antigens. Here, CD8A is linked to neoplasm.