CD8A and melanoma: In addition, CD8+ T cells secrete the CXCL13 protein during their transition from a predysfunctional to a late dysfunctional state, suggesting that this cell population may drive the formation of tertiary lymphoid structures (TLSs) associated with clinical outcomes.4 Therefore, further studies need to elucidate their roles in pro-/antitumor immune activity in the different stages of the differentiation trajectory in melanoma.