Notably, the presence of CD103+CD69+CD8+ TILs in melanoma, which is associated with a favorable immune response and identified potentially future targets, has been observed.5 However, Oliveira et al.1 did not divide CD8+ TILs into groups characterized by CD103+ and/or CD69+ through single-cell strategies, in contrast to the former study. The gene discussed is CD69; the disease is melanoma.