VHL and Dowling-Degos disease 1: The enhanced glycolysis program is a potential mechanism underlying the aggravated DDD development observed in VHL mutant mice in which the matrix is broken down by proteinases such as MMP13 and ADAMTS5 produced by degenerative disc cells, with decreased levels of collagen II and proteoglycan.45 Then, we investigated whether DDD progression could be alleviated by inhibiting glycolysis.