VHL and chronic myelogenous leukemia, BCR-ABL1 positive: IF staining analysis showed that deletion of the Hif1α gene in Vhl cKO mice restored mitochondrial activity, which was indicated by the higher expression levels of COX4 and TOM20 and lower expression levels of CML in EP and AF tissues compared with the levels in control mice (Supplementary Fig 8B, E–H).