To investigate the functional role of T cells in the exacerbated DSS-induced colitis under mPGES-1 deficiency, the course of DSS-induced colitis in mPGES-1−/− mice were studied upon CD4+ T cell depletion by the treatment with anti-CD4 monoclonal antibody (Clone GK1.5) prior to DSS administration (Fig. 9A). This evidence concerns the gene CD4 and colitis.