Additionally, the study revealed that T cells lacking mPGES-1–dependent PGE2 production have reduced colitogenicity, whereas mPGES-1 deficiency in non-lymphoid cells facilitates T cell–driven colitis [65]; the authors interpreted their findings as suggesting that the effects of PGE2 derived from T cells differ from those of PGE2 derived from other non-lymphoid cells. Here, PTGES is linked to colitis.