PTGES and Familial adenomatous polyposis: Further, a previous study investigated DSS-associated colon tumorigenesis in Apc∆14/+ mice, a mouse model of familial adenomatous polyposis and reported that mPGES-1 is abundantly expressed in infiltrating cells of colonic ulcerated sites and that some of the mPGES-1–expressing cells were vimentin-positive mesenchymal/fibroblast cells [66].