TARDBP and proteostasis deficiencies: Therefore, the fourth aim was to expand estimates of neuronal loss as a correlate of functional decline, including AD dementia, with estimates of the contribution of various proteinopathies (neurofibrillary degeneration, α-synucleinopathy with Lewy bodies, aggregation of abnormally phosphorylated TDP-43 protein, and amyloid angiopathy).