APP and Dravet syndrome: Consistent with expectations, the amyloid load in DS subjects, with a third copy of the APP gene, is approximately 2–3 times greater in DS subjects in the 43–49, 51–59, and 61–72 years of age groups (6.1%, 7.1%, and 6.5%, respectively) than in subjects with LOAD FAST 3–4, 5–6, and 7 (2.1%, 3.8%.