AFP and neoplasm: The univariate and multivariate analyses revealed that tumor size (HR [95%]: 1.592[1.313–1.930], P<0.001), periportal HCC (HR [95%]: 2.417[1.559–3.745], P<0.001) and AFP ≥ 400 (HR [95%]: 2.955[1.652–5.283], P<0.001) were independent prognostic factors for tumor progression after RFA (Table 4).