The univariate and multivariate analyses revealed that tumor size (HR [95%]: 1.553[1.151–2.095], P = 0.004), periportal HCC (HR [95%]: 2.200[1.111–4.358], P = 0.024) and AFP ≥ 400 (HR [95%]: 2.431[1.000–5.907], P = 0.004) were independent prognostic factors for LTP after RFA (Table 2). Here, AFP is linked to hepatocellular carcinoma.