Several studies showed that mutations in the BCL6 corepressor (BCOR) gene located on the X chromosome could be responsible for different diseases such as Lenz microphthalmia syndrome and oculofaciocardiodental (OFCD) in which cardiac defect is one of the main predominate phenotypes [74, 75]. The gene discussed is BCOR; the disease is microphthalmia, Lenz type.