Whereas SUN1 and SUN2 have both been reported to interact with lamin A, they appear to have different roles in lamin A mutation-associated laminopathies including Emery–Dreifuss muscular dystrophy (EDMD) and Hutchinson–Gilford progeria syndrome (HGPS) [40, 41], as well as in mammalian development [42, 43]. This evidence concerns the gene SUN1 and Hutchinson-Gilford progeria syndrome.