TNF and dermatomyositis: We investigated lenabasum’s effect on TNF-α, IFN-α, and IFN-β production by peripheral blood mononuclear cells (PBMCs) from DM blood and found that moderate and high concentrations of lenabasum suppressed TNF-α secretion, while all lenabasum doses (low, moderate, and high) suppressed IFN-α and IFN-β production [21].