For instance, Li et al. found that circ-HER2 encoded a novel protein HER2-103, which was crucial for triple-negative breast cancer (TNBC) cell proliferation and invasion, and its discovery identified that circ-HER2/HER2-103-expressing TNBC patients could benefit from the clinically approved HER2 antibody pertuzumab [23]. The gene discussed is ERBB2; the disease is triple-negative breast carcinoma.