Lastly, we explored whether the loss of CSF/ventricular space is due to potential brain parenchyma swelling and the contribution of KC/Gro cytokine to this pathology in the genetic ablation model, as we find KC/Gro, contribute to brain edema formation in ischemic stroke, was the most upregulated in the brain of genetic microglia ablation model. The gene discussed is CXCL1; the disease is ischemic stroke.