Herein, Wang et al. synthesized pH/redox responsive nanoparticles (SNRs) to co-activate the antigen exposure of tumor cells and the maturation of dendritic cells (DCs) in lymph nodes by sequentially inducing activation of ICD and toll-like receptor 7/8 (TLR7/8) for synergistic chemo-immunotherapy (Fig. 11a) [64]. The gene discussed is TLR7; the disease is neoplasm.