We found that PSTK-KO HCC cells have exhibited both reduced cysteine concentrations and lower TrxR activities (Fig. S7), consistent with CRISPR screening results that TXNRD1/TXNRD3 were associated with Sorafenib/Erastin treatment resistance in Hep3B cells (Fig. 2A). Here, TXNRD3 is linked to hepatocellular carcinoma.