Individuals with higher levels (> 75th percentile) of IgG and IgG3 antibodies against GMZ2.6c were older and presented a higher time of residence in malaria-endemic areas than individuals with lower IgG and IgG3 antibody levels (< 75th percentile) (mean ± standard deviation: 40 ± 18 versus 33 ± 15, P = 0.03, for IgG; 47 ± 17 versus 35 ± 16, P = 0.0002, for IgG3) (Fig. 11). Here, IGHG3 is linked to malaria.