Naturally malaria-exposed individuals predominantly had anti-GMZ2.6c IgG1 and IgG3 cytophilic antibodies, an important fact considering that it has been proposed that not only the acquisition of anti-malaria protective immunity would result from a delicate balance between cytophilic/non cytophilic antibodies, but also that IgG2 and IgG4 non-cytophilic antibodies with the same specificity could block the effector mechanisms of the cytophilic ones [18, 66, 67]. The gene discussed is IGHG3; the disease is malaria.