Both in females and males, total IgE and allergen-specific IgE (SX1) levels were higher in patients with a history of asthma (414 patients, 18.2% of the total cohort) or self-reported allergies (765 patients, 33.6% of the total cohort), as compared to patients without a history of asthma or allergies (Fig. 2). This evidence concerns the gene IGHE and allergic disease.