Besides, we didn’t detect any difference for serum tumor markers compromised alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), carbohydrate antigen 19–9 (CA19–9), carbohydrate antigen 12–5 (CA12–5) and carbohydrate antigen 15–3 (CA15–3) in between subjects with and without thyroid nodules (Table 6). Here, ENO2 is linked to thyroid nodule.