In a recent research in this field, Lorenzo-Almorós et al. reviewed large number of predictive and diagnostic biomarkers for GDM including protein and genetic biomarkers they concluded that reduction in liver-derived sex hormone blinding globulin (SHBG) and adiponectin, in combination with increased levels of RBP4, afamin, ficlon-3, and some specific MiRs could be a reliable measure for prediction GDM [26]. This evidence concerns the gene AFM and gestational diabetes.