Fifty-one patients with nerve system disease, including coma, syncope, disturbance of consciousness, dizziness, headache, epilepsy, spasm, neuralgia, and Alzheimer’s disease, etc., had IgM- and IgG-positive rates of 3.92% (2) and 3.92% (2), respectively. Here, CD40LG is linked to early-onset autosomal dominant Alzheimer disease.