Multivariable logistic regression analysis showed that having < 200 CD4 cells/μl (AOR 3.2, 95% CI 1.5–6.9; P = 0.003), not washing hands after contact with soil (AOR 2.5, 95% CI 1.1–5.4; P = 0.026), not washing hands before eating (AOR 3.1, 95% CI 1.5–6.4; P = 0.003), eating unwashed raw produce (AOR 2.5, 95% CI 1.2–5.3; P = 0.017) and absence of indoor latrines (AOR 6.2, 95% CI 1.5–25.9; P = 0.012) were independent predictors significantly associated with intestinal microsporidiosis among HIV/AIDS patients (Table 5). This evidence concerns the gene CD4 and AIDS.