Multivariate logistic regression indicated that age of 30–55 years (OR 1.903, 95% CI 1.005–3.603, p = 0.048), age of ≥ 55 years (OR 4.104, 95% CI 1.928–8.737, p < 0.001), and CD4 count of < 200 cells/μL (OR 2.005, 95% CI 1.008–3.985, p = 0.047) were associated with increased odds of stroke. This evidence concerns the gene CD4 and stroke disorder.