AKT1 and cancer: For example, TRAF4 has been reported to be involved in the TRAF4-AKT/NF-κB-Glut1/HK2/RSK4/Slug pathway, which regulates the proliferation, migration and EMT of various cancer cells, such as lung and breast cancer (Kim et al. 2017; Liu et al. 2018; Zhu et al. 2018).