Immunoglobulin-containing and proline-rich receptor-1 (IGPR-1), also known as transmembrane and immunoglobulin domain containing 2 (TMIGD2), is a novel cell adhesion molecule expressed on the surfaces of epithelial and endothelial cells that has become a promising matrix protein of interest due to its unique role at the endothelial-cancer cell interface [142,143]. This evidence concerns the gene TMIGD2 and cancer.