HELLS and telomere syndrome: Survival analysis revealed the potential prognostic value of HELLS, STMN1 in up-regulation DEGs and EPAS1, CXCL2, NQO1, IL6 in down-regulation DEGs, with high expression of HELLS, STMN1 and low expression of EPAS1, CXCL2, NQO1, IL6 suggesting a short OS in STS patients (Fig 4A).