In C elegans, the sole SWI/SNF ATPase, swsn-4, has a high degree of homology to both mammalian BRG1 and BRM, providing a unique opportunity to accessibly model the connection between the dual loss of BRG1/BRM associated with poor prognostic outcomes in NSCLC and cellular invasion in the AC. The gene discussed is SMARCA4; the disease is non-small cell lung carcinoma.