Exposing cultures of RPE cells to oligomeric Aβ1-42 has proven to be a good in vitro model of AMD: the oligomers stimulate oxidative stress, apoptosis, and secretion of pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor-α (TNF-α) [10–12]. This evidence concerns the gene TNF and age-related macular degeneration.