GPIHBP1 and hypertriglyceridemia: APOA5 deficiency leads to hypertriglyceridemia, which may reflect its role in the efficient association of TRL with LPL or GPIHBP1 on endothelial cells (52), possibly because APOA5 interferes with an inhibitory effect of ANGPTL3/ANGPTL8 on this association (53).