Deletion of either lipoprotein lipase (LPL; ref. 21) or glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1; ref. 22) causes severe hypertriglyceridemia, but mice only develop early atherosclerotic lesions at an advanced age. The gene discussed is GPIHBP1; the disease is hypertriglyceridemia.