IDH2 and acute myeloid leukemia: Ivosidenib (AG-120) and enasidenib (AG-221) are first-in-class inhibitors of mutant IDH1 and IDH2 (mIDH1 and mIDH2) (42, 43), respectively, which were recently approved by the FDA for the treatment of AML with IDH1 or IDH2 mutation.