Trials of telaglenastat in combination with osimertinib (kinase inhibitor) for treating EGFR-mutated stage IV NSCLC (77) and in combination with pembrolizumab/standard-of-care chemotherapy in patients with KEAP1/NRF2–mutated NSCLC are also under way (78). This evidence concerns the gene KEAP1 and non-small cell lung carcinoma.