Using flow cytometry, we examined the expression of CD6 and ALCAM on T cells and monocytes, respectively, from kidneys of both MRL/lpr and B6.Sle1yaa mice at older than 6 months of age when systemic autoimmunity and renal disease are well-established, and compared them to C567BL/6, a strain of mice that does not develop spontaneous autoimmunity. Here, CD6 is linked to kidney disorder.