When HCC cells are co‐cultured with ADMSCs or treated with ADMSCs‐CM, the apoptosis rate of HCC increases and the proliferation is significantly hindered, which is accompanied by the up‐regulation of P53 and retinoblastoma mRNA, as well as the down‐regulation of c‐Myc and hTERT mRNA levels. This evidence concerns the gene MYC and hepatocellular carcinoma.