The accuracy of IgM-free AIM for HCC detection related to NASH, HBV, and HCV was 87.1%, 60.9%, and 83.3%, respectively, and that in all the patients was 79.7%, indicating that IgM-free AIM has a higher clinical accuracy than AFP or DCP (Table 2). This evidence concerns the gene CD40LG and metabolic dysfunction-associated steatohepatitis.