We observed that in xenografts derived from A549 cells, the tumor volumes of the Ad-VT, gemcitabine, and paclitaxel groups were significantly reduced compared with those of the control group (Fig. 6a, b), with IHC showing that Ki-67 and P-gp expression was decreased and TUNEL staining was increased (Fig. 6c). Here, MKI67 is linked to neoplasm.