UBASH3B and neoplasm: UBASH3B encodes a protein with tyrosine phosphatase activity, that has been previously linked to advanced neoplasia.36 SNP rs7115089 is strongly associated with BMI,35 and is in LD (R2>0.8) with genetic variants linked to other cardiovascular and metabolic traits in GWAS studies.37–40 SNP rs7115089 is associated with differential methylation at our sentinel CpG (cg26684673), which we have previously shown to be associated with BMI in adults.8 SNP rs7115089 is associated with expression of UBASH3B (P=1.7x10-17).