Abnormal activation of the Wnt/β-catenin pathway by mutations in adenomatous polyposis coli, AXIN2, or β-catenin (CTNNB1) is responsible for the initiation of almost all colon cancers.6,239 Recently, researchers have reported that the Wnt/β-catenin pathway collaborates with AHCTF1 (also known as ELYS) to act as a superenhancer-mediated gene to drive colon cancer.240,241 In a study of 955 patients with stage I, II, III, or IV colon and rectal cancer from 1980 through 2004, CTNNB1 was associated with improved CRC-specific survival and overall survival only in patients with a BMI ≥ 30.242. Here, CTNNB1 is linked to rectal cancer.