Three key signalling molecules in the Wnt/β-catenin signalling pathway—Wnt3a, β-catenin, and Cyclin D1—are upregulated at the mRNA and protein levels in the adult spinal cord of SOD1 (G93A) ALS transgenic mice and are related to gliosis of the adult spinal cord in ALS transgenic mice.171. The gene discussed is WNT3A; the disease is amyotrophic lateral sclerosis.