APC and colorectal carcinoma: However, miR-106a-3p, miR-494, and miR-155 directly target APC, promoting the accumulation of β-catenin in the nucleus and upregulating the active transcription of the target genes c-Myc and cyclin D1.52–54 Highly expressed miR-92a-3p reduces the ubiquitin-mediated degradation of β-catenin by directly inhibiting FBXW7 and MOAP1 and promoting the progression of colorectal cancer (CRC).55 MiR-182-5p directly inhibits the expression of FOXO3a, preventing its binding to β-catenin, enhancing the interaction between β-catenin and TCF4, and then promoting canonical Wnt signalling.56