A new specific Wnt inhibitor, a size-tuned nanocluster (CAcluster) improved the tumour response to the PD1/PD-L1 immune checkpoint blockade in melanoma and colon cancer.300 In the parental ID8 murine ovarian cancer model harbouring a knock-out of p53 (ID8p53) and MISIIR-Tag spontaneous ovarian cancer models, CGX-1321(Wnt inhibitor) increased infiltrating CD8+ T cells in the TME and decreased tumour burden.304. The gene discussed is TP53; the disease is neoplasm.