Although the clinical trial showed C82 had few clinical effects on systemic sclerosis (SSc), microarray analysis C-82 treatment provide the possibility that C-82 with longer treatment to promote fat regeneration in SSc skin.274 Similarity, in another clinical trials of SSc, the researchers found that rituximab (RTX) relieved symptoms of patients with SSc by upregulation of Dkk-1.275. The gene discussed is DKK1; the disease is systemic sclerosis.