In contrast, the PKD1insG/+ pigs produced in this study (Supplementary Table S4) with a mutation introduced into exon 1 of PKD1 (c.152_153insG) by CRISPR-Cas9 exhibited a similar phenotype as human patients with ADPKD, including high penetrance of renal cyst formation. This evidence concerns the gene PKD1 and autosomal dominant polycystic kidney disease.