Heterozygous deletion of Scn1a (Scn1a+/-) in mice replicates the phenotypes of Dravet syndrome patients, including susceptibility to hyperthermia-induced seizures (Ito et al. 2013; Miller et al. 2014; Yu et al. 2006). The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.