In the subgrouping, we found that there was an inverse association between cagA genotype and gastric MALT lymphoma in the Asian population (OR 0.104; 0.036–0.307 with 95% CIs; I2: 95.6; Q-value: 23.08; p value: 0.08), while there was no meaningful association between cagA-positive strains and the development of gastric MALT lymphoma in Western countries (OR 1.30; 0.906–1.866 with 95% CIs; I2: 45.83; Q-value: 12.92; p value: 0.58). This evidence concerns the gene S100A8 and MALT lymphoma.