To elucidate the role of eEF2K pathway in the etiopathology of Dravet syndrome we deleted the eEF2K gene in Scn1a ± mice that was previously generated and described in Yu et al. [13] and mimic the Dravet syndrome described in human patients. Here, SCN1A is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.