ACPA-negative RA patients with early DAS remission, but without CRP levels ≥ 3× ULN at diagnosis, achieved SDFR as frequent as ACPA-negative RA patients without early DAS remission, which further supports the notion that the combination of both high CRP at diagnosis and early DAS remission is most discriminative. The gene discussed is PRTN3; the disease is rheumatoid arthritis.