Positive ANA were more common in the SN-APS/SP-aPL groups (OR = 3.3, 95% CI 1.8–5.9, p < 0.001, and OR = 2.0, 95% CI 1.1–3.6, p 0.026, respectively) than in the control group, even when adjusting for the presence of associated AID (OR = 3.1, 95% CI 1.7–5.6, p < 0.001, and OR = 1.9, 95% CI 1.1–3.5, p = 0.033, respectively). The gene discussed is BTG3; the disease is autoimmune polyendocrinopathy.