However, despite a systematic review reporting a similar recurrence rate to the general population in individuals with venous thromboembolism or stroke and only one single aPL determination [14], the included primary studies are scarce and outdated and have important methodological limitations, such as still not including anti-beta-2-glycoprotein I (anti-β2GPI) antibodies or inadequate aPL positivity cut-offs [15–18]. Here, APOH is linked to Stroke.