The results from our in vitro and in vivo studies demonstrate an unexplored role of adipocyte exosomal LncRNAs in MM drug resistance and the methyltransferase activity of METTL7A in RNA methylation in adipocytes, where MM cells promote packaging of LncRNAs into adipocyte exosomes by enhancing METTL7A activity through EZH2-mediated METTL7A protein methylation. The gene discussed is TMT1A; the disease is Miyoshi myopathy.