We found that inhibition of protein synthesis by cycloheximide reduced c-Myc protein levels in a similar pattern between the vector control and LOC606724-overexpressing MM cells (Fig. 4d), suggesting that the rate of protein degradation remains the same and may not be affected by LOC606724. While inhibition of protein degradation by MG132 enhanced the accumulation of c-Myc protein in MM cells, we observed more accumulation in LOC606724-overexpressing MM cells than in control cells (Fig. 4e), indicating that LOC606724 modulates c-Myc proteins in MM cells at the translational level. This evidence concerns the gene MYC and Miyoshi myopathy.