HNRNPU and Cushing syndrome due to macronodular adrenal hyperplasia: Next, we knocked down the expression of hnRNPA2B1 or hnRNPU in MMADs using specific siRNAs (Fig. 5e) and found that the knockdown significantly reduced levels of LOC606724 and SNHG1 in MMAD exosomes (Fig. 5f).