TNFRSF17 and neoplasm: However, the efficacy of targeting BCMA have showed promising but varied ORR ranging from 30 to 100%, or relapse occurs in a short time after CAR-T therapy, due to clonal evolution and loss of subclone in tumor cells, immunosuppression in bone marrow microenvironment, or exhaustion of CAR-T cells etc. [13, 14].