As shown in Fig. 1A and B, 18 of the 20 m6A regulatory genes were significantly upregulated in HNSCC tissues compared with normal tissues, including 6 “writers” (VIRMA, ZC3H13, METTL14, METTL3, WTAP, and RBM15), 2 “erasers” (FTO and ALKBH5), and 10 “readers” (IGF2BP2, IGF2BP1, IGF2BP3, YTHDF3, YTHDF2, YTHDC1, YTHDF1, HNRNPC, RBMX, and HNRNPA2B1). Here, METTL3 is linked to head and neck squamous cell carcinoma.