IGF2BP2 and head and neck squamous cell carcinoma: Moreover, immunofluorescent staining and confocal imaging analysis further confirmed that silencing IGF2BP2 led to a loss of vimentin expression, concomitant with a retention of E-Cadherin on the cell surface in both HNSCC cells, suggesting IGF2BP2 may regulate the EMT program (Fig. 5F).