High dose of QWS treatment decreased the expressions of TLR4, TRAF6, MyD88, p-IκΒα and NF-κB p65, as well as downregulated the ratio of p-IκBα/IκBα compared with T2DM + SH + OU group (P < 0.01). The gene discussed is RELA; the disease is type 2 diabetes mellitus.