In addition, the expression of apoptosis-related protein in tumor tissues were evaluated by Western blot analysis, and the results showed that knockdown of BDNF-AS significantly increased the ratio of cleaved caspase 3/total caspase 3 and cleaved PARP/total PARP (both p < 0.01) (Fig. 8H). The gene discussed is CASP3; the disease is neoplasm.