As a key element in cancer development, the miRNA/Bcl-2 signaling has been widely identified in different types of human disease, such as miR-34a in age-related hearing loss [50], miR-21 in gastrointestinal stromal tumor [51], miR-181b-5p in glioma [52] and miR-497 in MM [53]. The gene discussed is BCL2; the disease is presbycusis.