TLR4 and pancreatic neoplasm: Pancreatic cancer-derived sEVs induce ER stress-mediated apoptosis of T lymphocytes through the p38 MAPK pathway [56].Pancreatic cancer-derived sEVs downregulate TLR4 and downstream cytokines in dendritic cells(DCs) by miR-203, thereby inhibiting the immune response [57].