Following the study on the application of sEVs in pancreatic stellate cells, Yue Feng et al. found that pancreatic cancer cell-derived sEVs promote the recruitment of pancreatic cancer PSCs by activating the LIN28B /let-7/HMGA2/PDGFB signaling pathway through the transfer of the exosomal protein LIN28B to recipient cells [24]. Here, HMGA2 is linked to familial pancreatic carcinoma.