sEVs secrete by tumor-associated macrophage (TAMs) has been shown to transfer miR-501-5p into PDAC cells, and down-regulate TGFbR3 by activating the TGF-β signaling pathway to promote the metastasis and invasion of PDAC cells [15].As a medium of communication between pancreatic cancer cells and other cells, sEVs play a crucial role in the development of pancreatic cancer regardless of cell derivatives. This evidence concerns the gene TGFB1 and familial pancreatic carcinoma.