Ma et al. showed that compared with adjacent non-tumor liver tissues, the PD1Hi CD8 T cells were significantly enriched in tumors, and the PD1Hi CD8 T cells in liver cancer were highly expressed with depletion-related inhibitory receptors (TIM3, ctla-4, and so on) and transcription factors (EOMES, BATF, and so on) [37]. This evidence concerns the gene CTLA4 and neoplasm.