CCNE1 and liver cancer: We also analyzed the impact of CCNE1 expression on patient survival using TCGA human liver cancer data on UALCAN (http://ualcan.path.uab.edu/cgibin/TCGAsurvival1.pl?genenam=CCNE1&ctype=LIHC), Moreover, the results showed that the overall survival rate of liver cancer patients with a high expression of CCNE1 was significantly lower than that of liver cancer patients with a low expression of CCNE1 (Additional file 1: Figure S3).