CXCL12 and cancer: The 3 identified hub genes (Fig. 5C) in MCTVT, namely, CCL19, CXCL12, and C5AR1, participated in the top 1 and 2 (ranked by p value) enriched biological processes, “cell chemotaxis (Fig. 4, p = 0.0062)” and “positive regulation of neutrophil chemotaxis (Fig. 4, p = 0.0081)”, as well as in several cancer-related KEGG pathways.