Notably, it has been shown that GATA3 could promote leukemic transformation by driving MYC enhancer activity, and inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse [38, 39], suggesting a possibility that lncRNA-IUR1 is involved in Abl-induced tumorigenesis through regulating GATA3 expression. Here, ABL1 is linked to acute lymphoblastic leukemia.