To further address the functional involvement of lncRNA-IUR1 in Abl-induced leukemia, we generated a leukemia mouse model by injecting sub-lethally irradiated mice with control or lncRNA-mIUR1 knockdown GFP-positive NS2 cells stably expressing control or lncRNA-mIUR1 shRNA respectively (Fig. 5A). This evidence concerns the gene IUR1 and leukemia.